Role of organic anion transporting polypeptides (OATPs) for cellular mesalazine (5-aminosalicylic acid) uptake
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چکیده
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Fahrstr. 17, 91054 Erlangen, Germany (J.K., H.G., K.M., M.F.F.) Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, 17487 Greifswald, Germany (M.K.) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany (U.K.) DMD Fast Forward. Published on March 23, 2011 as doi:10.1124/dmd.110.034991
منابع مشابه
Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake.
The therapeutic effects and metabolism of mesalazine (5-aminosalicylic acid) in patients with inflammatory bowel disease require intracellular accumulation of the drug in intestinal epithelial cells and hepatocytes. The molecular mechanisms of mesalazine uptake into cells have not been characterized so far. Using human embryonic kidney cells stably expressing uptake transporters of the organic ...
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تاریخ انتشار 2011